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Cyclic neutropenia is an autosomal dominant genetic disorder with full penetrance but varying degrees of clinical manifestations; sporadic cases can arise from new germ line mutations.
The primary cellular abnormality in cyclic neutropenia is apoptosis of neutrophil precursors and their removal by marrow macrophages.
Cyclic neutropenia is usually diagnosed within the first year of life while in this case the disease was diagnosed in adulthood.
Human cyclic neutropenia transferred by allogeneic bone marrow grafting.
Complete blood count is performed 2-3 times a week for six weeks to differentiate cyclic neutropenia from severe chronic neutropenia.