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Related to cyclooxygenase inhibitor: prostaglandin inhibitor, Cyclooxygenase 2 inhibitor
See: deterrent
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In the study presented here, we employed leptin in conjunction with a well-known nonsteroidal anti-inflammatory agent and cyclooxygenase inhibitor, indomethacin, to examine the functional consequences of alteration in proinflammatory lipids generation by mucin-producing acinar cells of sublingual salivary gland in response to P gingivalis LPS-induced cPL[A.
Effects of nitric oxide synthase and cyclooxygenase inhibitors, and muscarinic receptor antagonist on Ch1LW-induced relaxation
1) Treatment of OA cartilage with commonly utilized cyclooxygenase inhibitors increases LTB4 production, which is associated with a marked change in the transcription of multiple cytokine and growth factor dependent genes which are prerequisite for normal cartilage homeostasis.
Pipeline candidates fall under major therapeutic classes such as VEGF inhibitors, angiogenesis inhibitors, C5a receptor antagonists, antioxidants, tyrosine kinase inhibitosr, clotting factor inhibitors, cyclooxygenase inhibitors, RPE inhibitors, antioxidants, PDGF inhibitors, chemokine inhibitors, IL-2 inhibitors, retinol protein binders, a51 integrin antagonist, protein C3 inhibitors and mRNA targeting agents.
cyclooxygenase inhibitors, inhibitors of cytokine generation); scavenging and quenching of ROS by antioxidants; inhibition of neutrophil elastase activity to prevent extracellular matrix damage and activation of matrix metalloproteases (MMPs), and inhibition of MMP expression (e.
As with all therapies, side effects with cyclooxygenase inhibitors can be expected, and lessons have been learned from the several nonprostaglandin-mediated mechanisms of action of NS-NSAIDs, demonstrated in experimental models.

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