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Histological features of the reaction were therefore, combined with the capillary tube technique [11,2] to detect the development of T-cell dependent CMI of the delayed hypersensitivity reaction which the main focus of this study.
Type IV reactions may also be involved in some delayed hypersensitivity reactions, such as celiac disease, in which there is a reaction to the gliadin fraction of grains and wheat gluten.
The delay in onset of the erythema and induration seen in our patient is consistent with a delayed hypersensitivity reaction to hirudin.
11-20] Dermatitis is a Type IV cell-mediated delayed hypersensitivity reaction commonly considered to be CD4+T-cell-mediated, not IgE-mediated.

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