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They were asked to classify the histopathologic pattern according to the 2002 ATS/ERS statement on IIP (1) as follows: UIP, nonspecific interstitial pneumonia, organizing pneumonia, diffuse alveolar damage, respiratory bronchiolitis, desquamative interstitial pneumonia, and other specific diseases.
The authors report the unusual occurrence of desquamative interstitial pneumonia (DIP) in a patient with HCV.
Given that most patients with PLCH are smokers, it is not surprising that the background lung parenchyma might show smoking-related changes including respiratory bronchiolitis, desquamative interstitial pneumonia, and/or emphysema (Figures 2, B, and 4, E).
These alterations have been described over decades as separate diseases, including emphysema, (4) respiratory bronchiolitis, (3) respiratory bronchiolitis-interstitial lung disease, (5) desquamative interstitial pneumonia, (6) and pulmonary Langerhans' cell histiocytosis.