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2) Recent experience is that IV CMS, administered as a 10 to 30 minute infusion at a dose of 5 to 6 mg/kg/d in 2 or 3 divided doses, does not appear to be nephrotoxic in patients with normal renal function. For patients with severe allergies, dosing may be increased to a maximum of 24 mg/day for adults (given in divided doses 6 to 8 hours apart). 36 mg/kg/day (72 x ADI) administered as two daily divided doses for 4 days in 12 human volunteers was designed and undertaken after results from a pilot study. |
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