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Because of the different W1/O, the droplets generated in the double emulsion would be in different size.
The one-step process was adopted in this study, since it is a more straightforward approach to obtain the double emulsion.
However, in the center region the double emulsion morphology which exists only at the low screw speed (40 rpm) also appears (Fig.
The preparation of PLGA CA using a double emulsion process has been optimized within our laboratory (14) for future use in both ultrasound triggered drug delivery and tumor targeting.