Nano-scale delivery systems coordinate the pharmacokinetics (PK) of drug combinations
after administration so that the optimal ratio of the two drugs is exposed to tumor cells for prolonged times while reducing drug exposure and toxicity to normal tissues.
Finally, the researchers showed that mice made "pre-diabetic" by giving them a diet laden with fat and sugar showed a similar spike in blood sugar when given the drug combination
Because of the facial disfigurement that leprosy causes, a treatment that works faster than the standard drug combinations
do would be welcome, Gelber says.
He estimated that the drug combinations
fail because of drug resistance in as many as 50 percent of patients in some populations.
Under terms of the agreement, Presage will receive upfront fees and research funding as well as development and regulatory milestones related to identification of successful drug combinations
Nasdaq: CPXX), a biopharmaceutical company that is transforming the science of combination therapy and developing products to improve patient outcomes in cancer, announced their successful R&D efforts to apply the CombiPlex technology platform to optimize the efficacy of anticancer drug combinations
incorporating molecularly targeted agents (MTAs).
As personalized medicine moves from the present emphasis on diagnosis and prognosis to therapy, the problem of searching for optimal drug combinations
uniquely suited to the genetic and molecular profile of each patient will need to be solved.
Poor life expectancy is no longer a rational argument" for denying a person a transplant in countries where the best drug combinations
are available, she says.
Recent studies of drug combinations
, including protease inhibitors, have indicated they can reduce levels of the AIDS virus in patients' blood.
This survey investigated the use of these drug classes for the treatment of mild, moderate and severe AD, as well as examining the use of drug combinations
Primary Human Cell Models Identify Potential Safe and Efficacious Drug Combinations
To counter this trend, various research teams are working on different regimens and drug combinations