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guttate psoriasis, pityriasis rosea, drug eruptions, and tinea infections) are the most helpful in establishing the diagnosis.
Some oncologists believe that the sorafenib-associated syndrome is the same as the drug eruption known as Ara-C syndrome, a painful erythematous palmar/plantar eruption seen in leukemia patients receiving intravenous treatment with cytosine arabinoside (Ara-C).
All drugs with reported side effects can have cutaneous side effects, and Litt's Drug Eruption Reference Manual includes hives as an adverse reaction for all of the drugs it lists.
Pilar Tornero and colleagues used patch testing and control oral challenge in patients with previous fixed drug eruptions to trimethoprim-sulfame-thoxazole or an unknown sulfonamide (Contact Dermatitis 2004;51:5762).
Primary interface dermatitides in this group include hypertrophic lichen planus (HLP) and lichenoid drug eruptions (LDEs).
Litt's drug eruptions & reactions manual, 17th ed.
Material is presented in 42 contributed chapters beginning with lupus erythematosus; dermatomyositis; scleroderma, Raynaud's phenomenon, and related conditions; and vasculitis, and ending with nail signs, oral mucous membranes, leg ulcerations, cutaneous drug eruptions, and systemic therapy for cutaneous disease.
It was reported that skin lesions developed in 10% of the patients receiving anti-TNF treatment, including eczema, drug eruptions, drug induced systemic lupus erythematosus, dermatomyositis, lymphamatoid papulosis-like eruptions, and psoriasis (11).

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