a privately held biotechnology company focused on in vitro applications of stem cells for drug discovery and development, announced today the initiation of a collaboration with the Mount Sinai School of Medicine (MSSM) for development of an in vitro drug toxicity
screening system based on proprietary human kidney cells and isolation techniques.
Role of the CAR Receptor in Drug Toxicity
Ciphergen is at the forefront of companies engaged in assisting clients to identify alternative predictive drug toxicity
methods based on its ProteinChip System and Arrays.
NASDAQ: CGEN) announced today it has signed an agreement with Teva Pharmaceutical Industries (NASDAQ: TEVA) to collaborate on a project for the discovery of biomarkers for the detection of drug toxicity
in preclinical stages of the drug development process.
Phospholipid nanosomes could lead to: (i) targeted delivery; (ii) enhancement of therapeutic efficacy; (iii) elimination of pre-medication to counteract toxic excipients; (iv) reduction of drug toxicity
side effects; (v) prolongation of circulation time and therapeutic effect; and (vi) improvement in quality of life.
Nicholas Onaca, MD, a transplant surgeon on the medical staff at Baylor University Medical Center at Dallas explains, "By using ImmuKnow, this study suggests that islet grafts can be maintained at lower levels of immunosuppression, but this raises the question whether graft loss from over-immunosuppression and drug toxicity
is more prevalent than graft loss from rejection.
If it is not possible to use alternative medications, physicians "should consider dose adjustments and monitor patients closely for evidence of drug toxicity
," they said.
Other groups have done specific drug toxicity
studies that have yielded further data.
The court also ordered further proceedings to determine whether the delay in treatment caused the inmate to suffer from prescription drug toxicity
New research presented this week highlights the ability of NextBio to help life scientists and clinicians investigate publicly available genomic data to assess biological mechanisms underlying drug toxicity
, as well as discover prospective cancer biomarkers for further validation.
There are concerns about overlapping drug toxicity
, and of hepatotoxicity in particular, but the advice is to use an efavirenz-based rather than nevirapine-based ART regimen.
Coroner Suzanne Anderson recorded that the victim died from mixed drug toxicity