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Recognition of the imaging milestones in postnatal brain maturation, primarily the process of myelination, is important in differentiating dysmyelination from degenerative processes.
Choline levels were found to be elevated which, while a nonspecific finding, may relate to dysmyelination.
Pelizaeus-Merzbacher disease (PMD) (9) and the allelic disorder spastic paraplegia type 2 (SPG2) are rare X-linked recessive dysmyelination disorders caused by sequence variations in the proteolipid protein 1 (PLP1) [10] gene (1-3).