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References in periodicals archive ?
The results from this study, as well as additional efficacy data from the dyspareunia cohort of the second Phase 3 study, are expected in the third quarter.
Lichen sclerosus typically presents with itching, burning, dyspareunia, and skin texture changes often described as "cigarette paper" skin, with crinkling and fissures around the vulva and anus.
The first Phase 3 trial for Ophena(TM) met all the co-primary endpoints at the 60mg dosage, with statistically significant improvements in vaginal dryness and dyspareunia, as well as statistically significant improvement in the proportion of parabasal and superficial cells in the epithelium of vaginal walls and a decline in vaginal pH levels.
Removal indications included symptomatic mesh erosion (63%), recurrent pelvic organ prolapse (42%), chronic pain (32%), and dyspareunia (32%).
Oral contraceptive pills, through their interaction with hormone receptors in the vestibule, may alter the vulvar mucosa, which may in turn become more vulnerable to external exposures or irritants and eventually increase local inflammatory response, pain at touch, and dyspareunia.
This is the first study with detailed, frequent and long-term follow-up to assess associations of dyspareunia with obstetric risk factors.
Stuenkel talks about two of the newer SERM options--ospemifene for dyspareunia and a combination of the SERM bazedoxifene and conjugated equine estrogens that's available outside of the United States--to treat vasomotor symptoms or for prevention of bone loss.
Many concerns have been raised by the FDA and patients who report recurrent POP, severe chronic pelvic pain and de novo dyspareunia possibly related to mesh erosion or retraction.
If functional outcomes are reported, they are limited to dyspareunia, urinary and defecatory dysfunction.
In PVA there are symptoms of redness, burning, itching, dryness, irritation, and dyspareunia.
Sexual problems such as dyspareunia, trouble in lubricating, anxiety about performance, lack of libido