The Phase II SOCRATES-REDUCED trial evaluated the tolerability and dosing of vericiguat in patients with worsening chronic heart failure and reduced ejection fraction
(HFrEF) already on standard of care therapy.
Chugh indicates that more analysis is needed to determine why patients with low ejection fractions
did not receive implantable defibrillators.
There were no significant differences between the low ejection fraction
and high ejection fraction
groups for the duration of inpatient rehabilitation, (45.
Pooled analysis of a total of 395 participants found an average net increase in ejection fraction
In the first study, researchers said "landmark clinical trials" had shown the aldosterone antagonists spironolactone and eplerenone cut deaths by up to 30% and readmissions for HF by nearly 40% in patients who had heart failure accompanied by reduced ejection fraction
First, the study population of patients with low gallbladder ejection fraction
(GBEF) was only 21 patients
The treatment with PycnoQ10 was found to significantly increase heart ejection fraction
After adjusting for factors shown to be confounders of this relation (age, diabetes mellitus, chronic obstructive lung disease, renal failure, ejection fraction
, and left main disease), the estimated association was no longer significant (P = 0.
That value, called ejection fraction
, has no direct relationship with the heart's electrical circuitry.
The guideline stipulates that ICDs should be used as a primary prevention therapy for heart failure patients with a low ejection fraction
(poor heart pumping function) to save lives from sudden cardiac arrest (SCA), and as a secondary prevention therapy for heart failure patients with a low ejection fraction
and a previous SCA or documented, sustained ventricular arrhythmias.
Despite an initial left ventricular systolic ejection fraction
of 20% and evidence of global hypokinesis on echocardiography, treatment with antithyroid agents led to rapid improvement in his clinical status and normalization of his ejection fraction
Patel and colleagues said the study involved 20 patients with severe heart failure who had ejection fractions
less than 35% (a patient with good heart function has an ejection fraction
of at least 55%).