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In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis virus.
The cardioviruses (family Picornaviridae, genus Cardiovirus) are pathogens of rodents and include a murine encephalomyocarditis virus and Theiler's virus and related strains (species Theilovirus), the latter serving as laboratory models of the pathogenesis of multiple sclerosis in mice (1).
To the Editor: Cardioviruses currently consist of at least 3 viruses: Theiler murine encephalomyocarditis virus, encephalomyocarditis virus, and Saffold virus (SAFV) (1-4).
Gender-determined differences in susceptibility to virus infections have been reported for encephalomyocarditis virus (34), vesicular stomatitis virus (35), and coxsackievirus B3 (36).
A wild-type porcine encephalomyocarditis virus containing a short poly (C) tract is pathogenic to mice, pigs, and cynomolgus macaques.

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