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The most common target organs for ethanol-induced end organ damage are the liver and the pancreas.
In animal models of hypertension, VTP-27999 demonstrated significant and sustained reductions in blood pressure, as well as beneficial end organ protection effects and enhanced survival.
More importantly, it has clearly shown beneficial end organ protection effects and enhanced survival in animal models of hypertension.
ZoraxelTM is a centrally acting, dual enhancer of neurotransmitters in the brain, whereas PDE-5 inhibitors only target end organ erectile function, and work in peripheral blood vessels.
Zoraxel(TM) is a centrally acting, dual enhancer of neurotransmitters in the brain, whereas PDE-5 inhibitors only target end organ erectile function, and work in peripheral blood vessels.
BENICAR and BENICAR HCT have not been FDA approved for other indications such as end organ disease or other hypertension related morbidity.
Renin inhibitors are likely to provide greater end organ (heart, kidney, brain) protection than currently available antihypertensive agents, based upon recently published clinical biomarker data.
We believe this first-in-class compound has great potential to be a unique 'antihypertensive-plus' drug that not only lowers blood pressure but also offers end organ protection of the heart and kidney, and protection against vascular inflammation.
We believe that future growth in transplantation requires a significant expansion in the treatment options for end organ failure as the supply of human donor organs is severely limited and the use of animal organs for xenotransplantation is still fraught with many uncertainties.