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In the initial clinical trial, the mean left atrial pressure for five patients, as determined by the SCMS, matched the left ventricular end-diastolic pressure, as determined by the left heart catheterization procedure, within 0.
4,5) These pathologic changes to the pericardium cause the pressure in both ventricles to rise early in diastole, with elevation of the end-diastolic pressure and reduction in ventricular filling.
Such patients, who were identifiable by an LV end-diastolic pressure greater than 18 mm Hg, accounted for roughly 40% of the study population.
Plasma big endothelin-1 concentrations exhibited a significant negative correlation with the left ventricular ejection fraction, and a significant positive correlation with the left ventricular end-diastolic pressure, the left ventricular end-diastolic and end-systolic volume indices, and the mean and end-diastolic pulmonary arterial pressure.