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The transplanted cells are able to engraft, migrate, differentiate into neurons and glial cells, and possess the ability to survive for as long as one year with no sign of tumor formation or adverse effects.
The Company has demonstrated that, when transplanted into an animal model of hypomyelination (shiverer mouse), HuCNS-SC cells engraft and differentiate into mature oligodendrocytes and form myelin sheaths around host nerve fibers.
They have demonstrated that human liver cells taken from adult stem cells - known as induced-pluripotent stem cells (iPSC) - coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.
The results demonstrate that the transplanted cells engraft, migrate throughout the brain and continuously secrete the missing lysosomal enzyme characteristic of NCL, which is needed to process cellular waste and keep neurons functioning and healthy.
Tengion, a clinical-stage regenerative medicine company, is focused on discovering, developing, manufacturing and commercializing a range of neo-organs, or products composed of living cells, with or without synthetic or natural materials, implanted or injected into the body to engraft into, regenerate, or replace a damaged tissue or organ.
The Company's preclinical research has shown that HuCNS-SC cells can be directly transplanted; they engraft, migrate, differentiate into neurons and glial cells; and they survive for as long as one year with no sign of tumor formation or adverse effects.
Zeng said this is the first time iPSC-derived cells have been shown to engraft and ameliorate behavioural deficits in animals with PD.
Within days, the sheets of cells permanently engraft, attach to the healing connective tissue, and differentiate into normal epidermis.
The human liver engrafting cells (hLEC) are a population of cells that are isolated from primary human tissue, engraft in vivo in animals and produce important human proteins that are missing or deficient in liver disease.
These stem cells in their syringes are able to maintain their stem-ness and are able to engraft at their organ specific sites once injected within 3 to 5 days from the date shipped.
The Company's preclinical research has shown that HuCNS-SC cells can be directly transplanted; they engraft, migrate, and differentiate into neurons and glial cells; and they survive for as long as one year with no sign of tumor formation or adverse effects.
But the blood-forming cells failed to properly engraft and produce new blood cells.
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