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The human liver engrafting cells (hLEC) are a population of cells that are isolated from primary human tissue, engraft in vivo in animals and produce important human proteins that are missing or deficient in liver disease.
In September 2007, we entered into a research collaboration with Belgium's Universite Catholique de Louvain (UCL) and the UCL-affiliated Cliniques Universitaires Saint Luc to further the development of our proprietary human liver engrafting cells (hLEC) as a potential cell-based liver therapy.
Luc Hospital) to further the development of the Company's proprietary human liver engrafting cells (hLEC) as a potential cell-based liver therapy.
Millan's paper, entitled "Long-term Engraftment of Human Liver-derived Stem/Progenitor Cells," will demonstrate that a population of human liver engrafting cells (hLEC) identified and isolated by StemCells, Inc.
Cellular transplantation is under evaluation by many groups as a potential treatment for a variety of liver diseases, but the clinical utility of such transplantation is currently limited by the inability to reproducibly extract the necessary numbers of liver engrafting cells.
The manuscript described a novel in vivo multiple myeloma (MM) model developed by engrafting a human multiple myleoma cell line into severe combined immunodeficiency (SCID) mice previously given implants of a human fetal bone chip.
The technology involves engrafting human immune cells into mice that lack a functional immune system.
It is also, we believe, a scientific milestone since to our knowledge no other technology has been successful in engrafting cells expressing a cloned gene in the bone marrow of adult subjects without first ablating the patient, a process in which blood cells are destroyed.