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Once-daily UltibroA BreezhalerA (indacaterol/glycopyrronium) 110/50 mcg met its primary endpoint (non-inferiority) and furthermore demonstrated superiority to twice-daily Seretide (salmeterol/fluticasone) 50/500 mcg in reducing the rate of all COPD exacerbations (mild/moderate/severe) over one year of treatment.
When stratified by genotype, there were no significant differences in hazard ratios for time to first exacerbation, mean number of exacerbations, or lung function at 6, 12, or 18 months.
Other risk factors for exacerbation included previous asthma exacerbations (OR, 1.
Mucolytic agents have an important role in managing COPD exacerbations because increased mucus secretions causes coughing and the mucus plugs can obstruct airways and lead to increased death.
roflumilast) significantly reduced exacerbations and hospitalizations in patients with severe chronic obstructive pulmonary disease (COPD), who are at risk of frequent and severe exacerbations despite already receiving inhalation therapy with ICS/LABA combinations or triple (LAMA/ICS/LABA) therapy.
In this review we considered the evidence that specific indoor environmental exposures might cause exacerbation of asthma.
Asthmatic patients often suffer exacerbations due to viral infections, including the common cold.
New GOLD treatment recommendations stratify patients with COPD on the basis of symptoms and exacerbation history.
It is again clear for COPD patients that these exacerbations are really hard to treat" and prevent, Janssens told.
The researchers found that vitamin D supplementation did not reduce the number of acute exacerbations of COPD nor improve lung function.
They experienced 4,439 episodes of worsening symptoms, slightly more than half of which resolved spontaneously and the rest of which resulted in a defined COPD exacerbation.