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Exosomes are microvesicles that are released by cells into the extracellular environment and contain important biochemical and molecular information reflecting the status of the cell of origin.
Creating a nanofiber network that enables us to more equally distribute cells and more closely mirror the actual cartilage extracellular environment are important advances in our work and in the field.
There are alternative explanations to the selective release of gene transcripts, however, including an insensitivity of the RT-PCR method to detect very low mRNA concentrations, or differences in mRNA stability in the extracellular environment.
Their data explain how TB4 may modify specific biological responses in an extracellular environment.