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coagulation |
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Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases. The extrinsic pathway is initiated by tissue damage and is primarily responsible for the desired clotting that occurs at the site of injury, limiting blood loss. |
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