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5,6) Furthermore, acute disseminated encephalomyelitis is often a diffuse white matter disease producing multiple lesions in the cerebral hemispheres, cerebellum, brainstem, and spinal cord, whereas CLIPPERS is a focal disease of the brainstem.
Perhaps the most important thesis in Louisa Williams's text is the examination of the patient for pathologic focal disease or focal infection.
It was based on estimates of total blindness in Africa that were probably not representative because they were extrapolated from areas that had particularly high levels of blindness, sometimes from focal diseases such as trachoma and onchocerciasis.

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