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There was significant presence of swelling of hepatocytes and focal necrosis.
In the single events we found out focal necrosis (Figures 1(e)-1(f)).
In Zones 1 and 2, the most significant alterations in the two species comprised an increase in the number of melanomacrophagous centers (MMCs), fatty degeneration, inflammation, hepatitis, congestion of the blood vessels and focal necrosis.
Histopathological changes in the liver of rats Microscopic observation Control Galactorsamine Silymarine 400 25 mg / kg mg / kg Hepatocyte - + + + + [Perpendicular to] degeneration Henpatic - + + + + - cell injury Parenchyma - + + + + - inflammatory Focal necrosis - + + + + - Vascular - + + + + - swelling Microscopic observation 50% Ext.
Typical pathological changes of DILI include: (1) steatosis: divided into macrovesicular and/or microvesicular; (2) cholestasis: brown bile particles are present in cytoplasm of hepatocytes with bile capillary dilation, forming obvious bile plug; (3) cell apoptosis: apoptotic bodies are present in hepatic cords and sinusoids; (4) hepatocyte necrosis: including the states such as spotty and focal necrosis, piecemeal necrosis/interface inflammation, and submassive and massive necrosis; (5) leukocyte infiltration: eosinophilic leukocyte infiltration in necrotic areas and portal areas; (7) intraepithelial granuloma; (8) and iron deposition.
The liver sections of Labeo rohita exhibited aggregation, hypertrophy of hepatocytes, cytoplasmic degeneration, hemolysis between hepatocytes, focal necrosis and degeneration.
Low-grade MEC have epithelial cells that show keratinization and small lumen forming glandular cells, high-grade MEC have epidermoid and mucinous cells with focal necrosis.
Besides, Antroq also prevented the development of focal necrosis, fibrin deposits, prominent leukocyte infiltration, apoptotic figures, and focal matrix accumulation/fibrosis along the arterial wall in the CAL mice.
Liver autopsy specimens of terminal DSS patients generally showed massive or focal necrosis with little or no recruitment of polymorphonuclear cells or lymphocytes (3,4).
Microscopy revealed an infiltrating neoplastic lesion composed of variably-sized anastomosing vascular channels lined by plump endothelial cells with areas of haemorrhage and focal necrosis.