First, those with advanced ovarian cancer had an average survival of 77 months as compared to 29 months for similar patients without the genetic mutation
By collecting data and samples over time from people who have not been diagnosed with the disease but who carry an associated genetic mutation
, researchers can test for characteristics that may denote greater risk of disease onset or, conversely, protection from symptoms.
Study leader Parry Guilford said the team used genomic screening to search for vulnerabilities in the cancer cells that lack the tumoursuppressor protein, Ecadherin, which was often lost because of a genetic mutation
Mice with the genetic mutation
gained weight even while eating the same amount of food as their normal counterparts; the affected gene, Mrap2, has a human counterpart (MRAP2) and appears to be involved in regulating metabolism and food consumption.
When used on cervical swabs, the experimental analysis spotted genetic mutations
in every sample from uterine cancer patients and in many from those with ovarian cancer.
SCIENTISTS at the University of Birmingham may have unlocked a key to understanding Parkinson's disease after discovering genetic mutations
that cause a rare childhood neurological disorder.
But even low doses of the antibiotics can cause serious permanent damage to the hearing of children with the genetic mutation
, researchers from University College London (UCL) said.
This trend may particularly impact women who carry BRCA1 and BRCA2 genetic mutations
, since cancers develop in these women at significantly younger ages than in noncarriers, and some studies have indicated that mutation carriers are more likely to develop cancer during pregnancy.
Additional larger studies are needed to confirm these findings and to explore the relationship between the genetic mutation
and depression, the researchers said.
Research by geneticist Stephen O'Brien has traced Crohn's Delta 32 mutation back hundreds of years to towns like Eyam, where the defensive genetic mutation
held off the black death in much the same way it now protects Crohn from HIV.
A study of a small group of centenarians and their aging children suggests that some fortunate families have a genetic mutation
that keeps their HDLs high despite inactivity, poor diet, or smoking.
ISLAMABAD -- The first genetic mutation
ever associated with a mysterious and potentially devastating form of heart disease that affects women in the final weeks of pregnancy or the first few months after delivery have been identified by researchers at the Intermountain Medical Centre Heart Institute.