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So, if the ES cells which have a null mutation in the genome aggregate with tetraploid embryos, null mutation pups can be produced directly without passing through the chimera selection and germ line transmission steps (Figure 8).
To assess the risk of germ line transmission in vivo, researchers used a mouse model to deliver human recombinant Ad5 carrying a germ cell-specific promoter fused to a reporter gene directly into the left ventricular cavity of the heart.