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Related to gramicidin: framycetin
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The ability of Aneurinibacillus migulanus (Bacillus brevis) to produce the antibiotic gramicidin S is correlated with phenotype variation.
Demain , Nutrition of Bascillus brevis ATCC 9999, the producer of gramicidin S in : Antimicrobial Agents Chemotherapy, Vol.
Gramicidin exists in a homodimeric form wherein both monomers of the protein reside in a linear conformation.
By the 1930s, he was a leading figure in microbiology, attracting talented graduate students, including Rene Dubos, whose work led to the discovery in 1939 of gramicidin, the first clinically useful topical antibiotic.
After gramicidin treatment, calibration solutions (0-250 mM NaCl, equimolar potassium substitution) were bath-applied.
They discovered that the new nanotubes conducted ions as effectively as the eight-ringed ones and more efficiently than gramicidin A, a natural peptide channel with antibiotic properties.