While small-molecule compounds are still a long way from the clinic, these results are another small step on the long road to a drug for hearing loss that could be infused into the cochlea to generate new hair cells
Our statistical analysis did, however, indicate that a duration of aminoglycoside treatment of 6 days or more might cause damage to the outer hair cells
Washington, Feb 21 ( ANI ): For years, scientists have thought that the sound-sensing hair cells
in the inner ear cannot be replaced once they're lost.
When hair bundle motion exceeds a certain level, the transduction channels begin to open, the hair cell
undergoes depolarization, and neurotransmitter release increases.
The implant uses 16 to 24 multichannel electrodes to replace the missing hair cells
, House said.
In the first-of-its-kind study, scientists at the University of Michigan Medical School discovered that infusing the Atohl gene into the inner ear of deaf guinea pigs triggered the growth of new auditory hair cells
as well as other supporting cells, resulting in improved hearing.
The damage that occurs slowly over years of continuous exposure to loud noise is accompanied by various changes in the structure of the hair cells
This is an area that's a bit more futuristic and ultimately restoring the hair cells
will be the cure.
For Lysakowski, this suggested a new way to envision how hair cells
Toxins and trauma share common pathways in hair cell
SPI-1005 treatment increases the expression of GPx1 and is thought to allow these affected cells and tissues to repair themselves, thus restoring auditory function and preventing the irreversible loss of auditory hair cells
and supporting cells.
As positively charged ions rush into the hair cell
, mechanical vibrations are converted into an electrochemical signal that the brain interprets as sound.