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We report a case of pleural involvement by adenocarcinoma, mimicking in the hematoxylin-eosin stain an epithelioid mesothelioma, correctly identified only after immunohistochemical and electron microscopic examinations.
1) We describe a pleural tumor with "typical" features of mesothelioma in the hematoxylin-eosin stain slide that with further studies was reclassified as adenocarcinoma.
The lesion described in our case, with microscopic features typical of an epithelioid mesothelioma in the hematoxylin-eosin stain, stained negative for calretinin, was resistant to hyaluronidase in the colloidal iron stain, stained positive for Leu-M1, and had short villi and luminal and apical junctional complex on electron microscopic studies diagnostic of adenocarcinoma.