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Fluids administered to achieve those goals in birds include crystalloids, colloids, and whole blood, (1,4,8) but, to our knowledge, only one previous study (4) attempted to compare outcome after resuscitation of hemorrhagic shock with different fluid types in birds, including a crystalloid, a colloid, and a hemoglobin-based oxygen carrier solution (HBOCS).
Results from one study showed that Hemopure restored brain oxygenation and stabilized hemodynamic parameters (such as blood pressure and cardiac output) following hemorrhagic shock (physical collapse caused by sudden, massive blood loss).
A snapshot of the global therapeutic scenario for hemorrhagic shock.
Urgent laparotomy is seldom indicated in unstable patients with hemorrhagic shock.
However, the adequacy of hypotensive fluid resuscitation is not well delineated as some studies have suggested that hypotensive crystalloid resuscitation to a MAP of 60 mm HG to 70 mm HG may be inadequate to prevent metabolic derangements associated with hemorrhagic shock.
The new therapy counters hemorrhagic shock by increasing the body's levels of NO gas, which, among other physiological functions, relaxes blood vessels and regulates blood pressure.
Rarer causes of hemorrhagic shock must be considered early in patients with retroperitoneal bleeding.
The hemorrhagic shock that results from severe trauma can cause organ dysfunction and even death," said Karim Brohi, global principal investigator of the study.
Hemorrhagic Shock Global Clinical Trials Review, H2, 2012" provides data on the Hemorrhagic Shock clinical trial scenario.
This product is targeted as a therapy for treating gastrointestinal (GI) breakdown and multi-organ failure that often result from hypovolemic or hemorrhagic shock experienced by severe Ebola patients.
Childs and colleagues at Scott and White Healthcare looked at how female versus male rats fared after suffering a trauma and subsequent hemorrhagic shock that were given Estradiol (estrogen).
NASDAQ: OXBT), a development stage biomedical company focused on developing oxygen-carrying intravenous and topical products, announced today that it has entered into a Cooperative Research and Development Agreement (CRADA) with the Naval Medical Research Unit of San Antonio (NAMRU-SA) to assess the safety and efficacy of Oxycyte([R]) as well as hemoglobin-based oxygen carriers (HBOC) as potential resuscitation treatments for hemorrhagic shock.