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Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs.
The expression of enhancer of zeste homolog 2 (EZH2) relative to the clinical outcomes in locally advanced AJCC (American Joint Committee on Cancer) pathologic tumor stage T3 and above (A and C) and metastatic renal cell carcinoma (RCC) (B and D).
18] mutations inherited together on the same chromosome homolog (in cis, Figure 2A) or on separate homologs (in trans, Figure 2B).
Should a p80 homolog be present in plants, it might be involved in microtubule organization, and help to define the microtubule organizing center in plants.
The human homolog of insect-derived growth factor, CECR1, is a candidate gene for features of cat eye syndrome.
The MALDI-TOF MS results were successful at identifying two proteins: an endo-1,4-2-gluconase homolog (BAB95553) and a hypothetical protein (BAB96202).
UNA the homolog of LEY/FLO, is another floral menistem identity gene, but it also plays a role in leaf development (Hofer et al.
One such homolog, Bak (for Bcl-2-homologous antagonist/killer) appears to be involved in the death of long-lived terminally differentiated cells of major organs.
The approval of Pfizer's Xalkori (crizotinib), which treats only 5% of the total Non-Small Cell Lung Cancer (NSCLC) patient population, and the change in Erbitux's coverage of the colorectal cancer patient population (from every patient to wild type V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) patients) indicates a shift in focus to more personalized cancer treatment.
The most common somatic mutations identified were in the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and GNAS complex locus (GNAS) genes.
Similarly, knocking down expression of a human homolog in cultured human cells boosted the expression of stress-response genes that, again, like yeast, occur in DNA-damage repair pathways.
Calithera will also continue to develop its pipeline of novel therapeutics, including an inhibitor of MCL-1, an anti-apoptotic BCL-2 homolog over-expressed in many cancers.