Instead, the Ap bacteria set themselves up comfortably inside granulocytes and steadily grow for a few days until they rupture their host cells
and generate a strong immune response--making an infected person sick.
The team first extracted mRNA from a heart cell, then put it into host cells
RNA: Genetic blueprint enables virus to replicate once it has infected host cell
by hijacking cell's protein-making factory
In their investigation, the researchers identified hundreds of microscopic "arms," called P-pili, that enable the bacteria to cling to a host cell
To attack the host cell
, the weapon must first attach.
Once infected, the host cell
then produces new virus particles.
One of the chief mechanisms by which bacterial pathogens manipulate and interact productively with their host is through the secretion of specialized proteins with a variety of biological functions ranging from frank host cell
toxicity to more subtle alterations of the host cells
' own programmes to the benefit of the invader.
Four excellent chapters describe 6 secretion systems among bacterial pathogens and elucidate the specific mechanisms by which bacterial pathogens usurp intracellular mechanisms of the host cell
University of Pennsylvania, Philadelphia, for his work studying the interactions between proteins that allow HIV to recognize and enter a host cell
, research that potentially will lead to drugs that prevent the virus-cell fusion process; Nouri Neamati, Ph.
Targeting both the virus itself and host cell
factors that contribute to pathogenesis may be the ultimate strategy for treating certain viral diseases.
When the Plasmodium falciparum and Toxoplasma gondii parasites invade a host cell
, they take up residence inside a "parasitophorous vacuole" (PV), growing and replicating themselves for about 48 hours.
Chiron Corporation (Emeryville, CA) has patented compositions and methods for expression of heterologous mammalian proteins and their secretion in the biologically active mature form using a yeast host cell
as the expression system.