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Related to hypoferremia: sideropenia
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Phase I clinical studies demonstrated that treatment with NOX-H94 was generally safe and well tolerated and that NOX-H94 could prevent endotoxin-induced hypoferremia in healthy subjects.
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs.
The Phase I program consisted of a comprehensive single and multiple ascending dose study in healthy volunteers and a subsequent human pharmacodynamic study to assess the ability of NOX-H94 to prevent endotoxin-induced hypoferremia in healthy subjects.