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The induction of immune dysregulation by HIV may result in hypergammaglobulinemia, suggesting an abnormal polyclonal B-cell activation and immune complex glomerulonephritis in these patients.
Vascular etiology alone is probably not sufficient to explain the lack of immune complex deposition in glomeruli with periglomerular fibrosis.
The removal of immune complexes lessens the damage to blood vessels and organs triggered by immune complex deposition.
There are, of course, several classes of Fc receptors, and as we know from studies of animal knockout models, FcR3 is the dominant receptor that mediates joint inflammation during immune complex arthritis.
anti-ssDNA antibodies), and immune complex formation and deposition in renal glomeruli.
Two potential sources of the differences in fold improvement provided by immunoRCA are the affinity of the antibody pairs in the immune complex and the possibility that the immune complex formed by some antibody pairs may be sensitive to the RCA reaction buffer conditions.
In the kidney, these vascular lesions have been classified as (1) uncomplicated vascular immune complex deposits and (2) noninflammatory necrotizing microangiopathy, also referred to as lupus microangiopathy.
In addition, this method measures all delayed allergic paths: All antibody types (IgG, IgA, and IgM), immune complex reactions (IgM anti-IgG antigen complexes), and direct T lymphocyte cell-mediated delayed immune reactions.
Ultrasensitive and rapid enzyme immunoassay (thin aqueous layer immune complex transfer enzyme immunoassay) for antibody IgG to HIV-1 p17 antigen.
By targeting the foreign antibody ProstaRex(TM) to the circulating PSA, an immune complex can be formed that is processed as foreign by antigen presenting cells including dendritic cells.
The study demonstrates that MUC-1 in the form of an immune complex is more efficiently processed than MUC-1 alone, leading to T helper cell stimulation and an enhanced cytotoxic T lymphocyte (CTL) response.
The ArthritoMab(TM) monoclonal antibodies were selected to bind to the epitopes C1, J1, U1 and D3 - which are spread over the entire CII region (fragments CB8, CB10 and CB11) encouraging better immune complex formation on the cartilage surface for the initiation of arthritis.