paralysis

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At moderate concentrations of bacteria, the model replicated the two trajectories of SIRS/MOF of most interest to medical researchers: organ failure and immune paralysis due to excessive inflammation.
They explained that Tat, which has been found to be essential for HIV replication and is secreted outside of an infected cell, and interferon alpha, a normal human cellular protein which is overproduced in HIV-infected people, both inhibit proliferation of T-cells, contributing to immune paralysis observed in AIDS patients.
In other words, while sepsis is triggered by a hyper activation of the immune response, most sepsis patients actually die from immune paralysis.