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One hundred patients were modeled at each combination of bias and imprecision for 100 h with each treatment regimen.
The maximum bias in the expression is valid only in cases when the imprecision equals zero.
est]) for each result was calculated by linear interpolation from the intermediate imprecision QC data.
A simulation model that considers bias and imprecision separately has been used to model the effects of glucose meter error on subcutaneous insulin dose (15).
When assay validation is done properly, modest increases in imprecision above 10% (up to 25% CV) inherently increase the 99th percentile value and thus protect against false-positive values (6).
It is confusing to present the 2 error sources, total imprecision, and random interferences as 1 combined error source, because these 2 error sources are quite different.
To use the 99th percentile irrespective of assay imprecision is an attractive suggestion because this would be simpler and less arbitrary than a 10% CV cutoff (which corresponds to a different cTnI concentration on every platform).
We previously showed that a change in the theoretical imprecision profile of a cardiac troponin assay (i.
To investigate the influence of assay imprecision on the likelihood of misclassifying healthy individuals or patients without myocardial injury, we simulated the distribution of cardiac troponin I (cTnI) results in a general population and added random analytical error reflecting different assay imprecision profiles.
Within-run imprecision (CV) was determined by measuring six different control samples 21 times in one run.
Comparison of NCEP clinical and analytical requirements with operating imprecision derived from OPSpecs charts.