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The technology uses germicidal low-pressure UV light emitters to disrupt the DNA and RNA of microbial cells, thereby inactivating them.
It acts by inactivating an enzyme called cyclooxygenase-2 (COX-2), which plays a role in inflammation.
New methods of inactivating pathogens would be especially advantageous for reducing bacterial contamination of platelets, which are particularly vulnerable because they must be stored at room temperature, says Roger Dodd, president of the American Association of Blood Banks in Bethesda, Md.
In addition, r-gelonin may be reproducible manufactured using standard recombinant techniques, and appears to be considerable less immunogenic than other ribosome inactivating enzymes.
This study demonstrates the feasibility of inactivating Avian Influenza A virus in water without introducing potentially harmful chemicals," said University of Minnesota Professor of Virology Sagar Goyal.
The product of one such gene is a protein known as silent information regulator 3, or Sir3, which clings to the genes responsible for stress proteins, thereby inactivating them and keeping them silent.
These studies have clearly demonstrated the potential applicability of AnergiX compounds in inactivating pathogenic antigen-specific T-cells for the treatment of certain autoimmune disorders," stated John W.
The INTERCEPT Blood System is designed to reduce the risk of transfusion-transmitted diseases by inactivating a broad range of pathogens such as viruses, bacteria, and parasites that may be present in donated blood intended for transfusion.
E-beam irradiation is highly effective for inactivating foodborne microorganisms, and in this manner can improve the microbial safety and shelflife of food.