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Related to indinavir: nelfinavir, saquinavir
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Significantly more patients withdrew from the study due to non-fatal clinical adverse events in the indinavir arm than in the saquinavir arm (28 percent vs.
Further, no primary indinavir mutation could be found in the plasma of these patients.
Kidney stones were not reported as an adverse effect from ritonavir, as had been the case in 2 to 3 percent of patients taking indinavir.
Additionally, at week four, fasting total cholesterol, LDL cholesterol and triglyceride levels increased more from baseline in the boosted indinavir arm versus the boosted saquinavir arm: 17 percent versus 9 percent, 21 percent versus six percent and 29 percent versus 13 percent, respectively (p<0.
However, experts believe that indinavir and ritonavir, another protease inhibitor being tested by Abbott Laboratories, are considerably more powerful.
Patients in the control group received treatment with a standard-of-care triple combination regimen of ZDV, 3TC and indinavir.
evaluated a combination of indinavir (800 mg) and ritonavir (200 mg) with reverse transcriptase inhibitors twice daily as a rescue regimen in treatment experienced patients (Abstract 27).
Indinavir can induce hypertensive crises in some patients, according to Dr.
Among the data are interim 24-week results of the first randomized trial to compare twice-daily regimens of FORTOVASE or indinavir (Crixivan(R)) with mini-dose ritonavir, known as the MaxCmin1 trial, as well as data from the FORTOGENE trial, which examined FORTOVASE with mini-dose ritonavir in heavily pre-treated patients.
Clarithromycin appears safe with indinavir or amprenavir.
In contrast, patients receiving the PI indinavir demonstrated significant increases in total and LDL-cholesterol, as well as an increase in the total/HDL-cholesterol ratio, a profile which in other settings carries an increased risk of coronary artery disease.