The fourth preclinical study demonstrated that GX15-070 induces
apoptosis in samples from leukemia patients carrying the t(4;11) mutation, which often causes resistance to standard chemotherapy.
In the present study, BPA was found to significantly induce
luciferase activity at doses of 1,000 and 10,000 [micro]g/kg 8 hr after exposure.
The authors conclude that CA4P selectively targets endothelial cells (flat-shaped cells that make up the inside of blood vessels) but not smooth muscle cells (cells which surround most blood vessels), and induces
regression of unstable, newly formed vessels by disruption of Vascular Endothelial-cadherin (VE-cadherin) signaling.
We have also investigated interactions of kaempferol, quercerin, myricetin, and luteolin as AhR antagonists in MCF-7 and HepG2 cells (Figure 6) because these compounds alone at concentrations of 1 or 10 [micro]M did not induce
luciferase activity in these cell lines (Figures 3 and 4).
up-regulation of blood-brain barrier functions by activating AMP-activated protein kinase in rat brain microvascular endothelial cells.
Apparently, the minimal level of MAPK activation required to induce
a large amount of TNF-[alpha] was higher than the levels of MAPK in cells after exposure to a single dose of Pb alone or LPS alone.
Most importantly, infection and current vaccines do not appear to effectively induce
these antibodies in humans.
But how to induce
a strong anti-HIV immune response?
Cyclacel Limited, the UK-based biopharmaceutical company, has demonstrated through state-of-the-art biomarker technology that CYC202 (R-roscovitine), its lead CDK inhibitor drug candidate, appears to induce
cancer cell suicide or apoptosis in patients receiving the drug.
Here, although one person with an extremely strong personality structure is able to induce
others to his or her way of thinking or beliefs, a true folie requires some kind of feedback to occur (the induced personalities must also respond) until a whirlpool of delusional communications is created that is so strong at times it is difficult to tell who is the original inducer and who is the inducee.
The Planned Parenthood Federation of America announced Wednesday that it would give some women seeking early abortions the option of taking medication to induce
abortion as part of a clinical trial approved by the Food and Drug Administration.