Cutaneous manifestations of EF have been described as progressive, with the earliest stage being edema of the extremities, followed by peau d'orange with hyperpigmentation, and finally induration
purified protein derivative antigen quality and manipulation, skin induration
interpretation, and injection dose protocols) (15).
Physical examination showed less induration
of the skin, resolution of the periungual erythema, and increased range of movement of the fingers.