In this article, we demonstrate that Pb(II) and Fe(II), and to a lesser degree Cd(II), inhibit
Ape1 nuclease activity, unveiling a novel molecular target for these environmental metals.
AgION's technology is based on naturally-occurring silver which inhibits
the growth of microorganisms such as bacteria, mold and fungus.
the vascular relaxation induced by acetylcholine in a concentration-dependent manner and that possible mechanisms are the inhibition of NO production in endothelial cells and the suppression of cGMP-dependent relaxation mechanisms in smooth muscles.
As early as 1972, another group of scientists found test-tube evidence that acetaminophen could inhibit
COX enzymes--which had yet to be subdivided into COX-1 and COX-2--in brain cells.
AgION Technologies, located in Wakefield, Massachusetts, is a leader in providing customized antimicrobial solutions based on silver that continuously inhibit
the growth of bacteria, mold and fungus.
Maitotoxin, a calcium channel activator, inhibits
cell cycle progression through the G1/S and G2/M transitions and prevents CDC2 kinase activation in [GH.
The active compound was able to inhibit
the varicella zoster virus much more quickly than acyclovir, one of the frequently used and currently approved therapies for shingles.
Though diets rich in vegetables inhibit
cancer development, Talalay's group is one of the few to execute "the very difficult, nitty-gritty studies" of the mechanisms, says Lee W.
ARIAD's preclinical kinase inhibitors fall into two classes: inhibitors of key mutant kinases that confer resistance to current therapies and compounds that inhibit
multiple pathways associated with cancer progression, such as metastasis, angiogenesis and survival.
Yet tumors sometimes arise, and researchers are now finding evidence that the cells of those cancers have found ways to inhibit
apoptosis, the process by which cells kill themselves (SN: 7/27/96, p.
These proteins may inhibit
nerve growth and may prevent nerve regeneration after injury.
While the Japanese researchers have not yet determined the chemical mechanism by which saponins inhibit
alcohol absorption, they have divided the inhibiting compounds into three classes according to their chemical structure.