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We may only speculate that oral thyroxine is administered as sodium salt that is less lipophilic than the native hormone, which enters target cells both through passive diffusion and in a carrier-mediated, inhibitable way.
The water-soluble fraction of UPs was sufficient for inducing ERK1/2 and p38 phosphorylation, which was also losartan inhibitable.
Through the application of functionally intact and pharmacologically inhibitable analog sensitive kinase alleles (ASKAs) and proprietary P-Target(TM) and P-Inhibitor(TM) platforms, this broadly enabling chemical genetic technology has been applied to protein kinases, an important class of drug targets across multiple clinical indications, including cancer, inflammatory, and autoimmune diseases.