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CYC202 (R-roscovitine) is a novel cell cycle drug belonging to the Cyclin Dependent Kinase (CDK) inhibitor class.
The first study tested the diuretic chlorthalidone against the ACE inhibitor lisinopril and amlodipine, a calcium-channel blocker.
Ritonavir was the first protease inhibitor to demonstrate a decrease in disease progression or death when administered to patients with advanced HIV infection.
These amino acids flank the HIV-1 capsid-SP1 cleavage site and the results suggest PA-1050040 may bind differently than bevirimat to this region of the viral Gag protein, which is the target for maturation inhibitor activity.
We also saw data about other new classes of drugs, including many other entry inhibitors, CCR-5 inhibitors, and one drug from a completely new class that may be a viral assembly inhibitor.
Nelfinavir-resistant virus may retain sensitivity to other protease inhibitors; however, virus resistant to other protease inhibitors is likely to exhibit resistance to nelfinavir as well.
The data indicated that GX15-070 induced apoptosis in several types of hematological cancer cell lines, both as a single agent and in combination with other cancer drugs such as rituximab, proteasome inhibitors, other Bcl-2 inhibitors, and chemotherapy agents such as CDDP and doxorubicin.
One of the most attractive things about a boosted protease inhibitor as a starting regimen is not only its potency, which is clear and established, but also this high genetic barrier to resistance.
Amprenavir in protease inhibitor experienced patients.
efflux-pump inhibitors might well represent economically and therapeutically promising drugs," he says.
Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction.
In 48-week data presented at the Retroviruses conference, this protease inhibitor did not increase blood cholesterol, LDL cholesterol, or triglycerides in treatment-naive patients (6) -- suggesting that it may be useful in developing HAART treatment regimens with fewer side effects.

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