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33), (34)Induction BCG instillations are classically given according to the empirical 6 weeks induction schedule, and many different maintenance schedules have been used with up to 30 instillations given over three years.
13) Iatrogenic harm has been caused by physicians' continued reliance on invasive surgery and bladder instillations to treat IC--a condition with no specific definition or diagnostic marker while patients report that these invasive treatments are not beneficial for most of them.
In another prospective randomized trial, Gulpinar and colleagues assigned patients to treatment with perioperative MMC followed by subsequent BCG instillations (once a week for 6 weeks), or treatment with BCG alone.
The authors of the study stated, "There are potential problems when utilizing bladder instillation 'cocktails' with anesthetic agents that are publicized with little or no supporting evidence.
Intravesical instillation of BCG has been used in the treatment of intermediate and high-grade bladder carcinoma in situ since 1976 and has been proven to be safe and effective.
Purpose: The aim of this phase lb/Ila study was to investigate the maximum tolerable concentration of Abnobaviscum[R] Frax-ini 20 mg for intravesical instillation in patients with superficial bladder cancer.
A total amount of 40 mg of MMC was administered in 60 min but, to avoid the drug degradation throughout the entire procedure, the dose was delivered with two 30-min instillations of 20 mg/50 mL bidistilled water.
A phase II clinical study of frequent instillations (2 drops per instillation, twice a day) of UF-021 (Unoprostone) Eye Drops, which are under development at our company for the treatment of retinitis pigmentosa, (Note 1) has been completed.
According to the American Urology Association bladder instillations are considered a second line treatment option when self-management treatments do not provide symptoms relief.
25,26] However, false positives with fluorescent cystoscopy can be increasingly induced by inflammation, recent TUR or intravesical instillations.
Prior to treatment and after 2 or 3 rounds of intralesional instillations, apoptosis induction was determined.