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Traditional use of random insertion to introduce a DNA construct into the human genome may lead to gene disruption, variable epigenetic effects on transgene expression and presence of an unknown number of integrants in each cell, making comparisons difficult between isolated single cell clones.
That opposition has proved to be extremely risky business for the movement's many integrants.
The Board of Directors also decided to constitute a temporary special independent committee composed exclusively by integrants of the management of the Company, mostly independent, to negotiate the conditions of the incorporation of the totality of Amil Assistencia's shares by Amilpar and submit its recommendations to the competent corporate boards, in accordance with Indication Statement CVM 35/08 ("Independent Committee").