coli was accompanied by an increase in monolayer permeability (seen as a decrease in the TEER), we suggest that the cytotoxic factor secreted by SEPEC 15 facilitates its passage through the endothelial barrier by a paracellular pathway following alterations in the functional intactness of the intercellular junctions
Nonspecific staining was present in some control cases; these were associated with debris and exudate, or stained in a homogeneous, mostly cytoplasmic pattern (Figure 1, F through H), instead of the distinct, condensed, continuous immunoreactivity localized to the intercellular junctions
of keratinocytes, as seen in pemphigus.
Numerous studies have shown that the intercellular junctions
and, in particular, the tight junctions regulate the permeability of the paracellular spaces and limit "water leakage.
And no direct contacts between TCs and elastic membrane and no intercellular junctions
between TCs and vascular SMCs (VSMCs) were observed [Figure 1].
Ultrastructural examination reveals epithelial cells joined by intercellular junctions
, including desmosomes and junctional complexes, with lumen formation.
The cytoplasm of esophageal cells contains numerous mitochondria and a well-developed GA, and their intercellular junctions
On observation with optical microscopy, we detected a dense structure of the CL tissue with more adherent intercellular junctions
in the middle stages than in the early and late stages.
Moreover, the intercellular junctions
of the mucosal epithelia provide a mechanical barrier to protein absorption.