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These discoveries follow the identification by Algene, in October 1996, of five chromosomal regions likely to harbour genes associated to late-onset Alzheimer disease.
This appears to be the second late-onset Alzheimer disease gene, and there are likely to be other important genetic variants that need to be identified before the entire picture is complete," said Richard Mayeux, M.
Cerebrospinal fluid 0-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.