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Related to light chain disease: kappa light chain, LCDD
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Serum free light chain assays may detect increased concentrations of light chains in the serum but do not establish their monoclonality and cannot differentiate between light chain disease and IgD or IgE myeloma.
We studied a 62-year-old man with light chain disease (multiple myeloma) whose urine protein electrophoresis (UPE; electrophoresis performed on agarose gel on a Panagel high resolution electrophoresis system; gel was stained with Amido Black) showed >15 narrow bands in the [beta]- and [gamma]-globulin regions; many of the bands were strongly stained and equidistant (Fig.
In the discussion of the workup of hypogammaglobulinemia, one could argue that urine immunofixation and not urine protein electrophoresis should be ordered to exclude the possibility of light chain disease.