pathway

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These data indicate that the inhibition of COX in OA cartilage results in the increased utilization of arachidonic acid substrate by the lipoxygenase pathway.
Two key members of the lipoxygenase pathway, 5-lipoxygenase (5-LO) and 15-lipoxygenase (15-LO) have been indicated in a number of diseases states including asthma, arthritis, atherosclerosis, diabetes, osteoporosis, and cancer.
Monohydroxylated fatty acids are synthesized from a wide range of polyunsaturated fatty acids and mainly derive from the lipoxygenase pathway activation [1,2].