Six patients died, but 7 survived an average of 4 days after liver cell
injection before receiving their transplants.
A gene therapy that targets RNA within liver cells
can halt hepatitis B virus (HBV) infections in mice, according to researchers at Stanford University in California.
The ground-breaking research on the liver cell
therapy is currently being developed by the Cytonet in partnership with the University Hospital of Heidelberg.
The Fa2N-4 cell line has also been engineered to function as a proxy for normal human liver cells
for use in performing drug toxicity assays.
Equally important, I consider HepaLife's PICM-19H cell research of particular significance since it directly addresses the widely-held scientific opinion that the greatest hindrance in development of a therapeutically effective artificial liver device has been the lack of an appropriately defined liver cell
line, able to provide the functions of an intact liver," Soheili concludes.
The ability to retrieve liver cells
with therapeutic potential from livers that cannot be used for transplantation could have two major benefits.
Wiser says that permitting even one infected liver cell
to escape immune surveillance could lead to full-blown malaria.
In a feat that could lead to new medical treatments, researchers have grown healthy liver cells
on silicon chips.
HepaLife's liver cells
demonstrate ability to function and survive without feeder cell support, following successful room temperature and human plasma survival outcomes; findings crucial to artificial liver device.
Chan and colleagues in his Baylor College of Medicine laboratory, in which they cured mice with type 1 diabetes by using a gene to induce liver cells
to make insulin.
Trials of liver cell
infusion also are underway at the University of Nebraska Medical Center in Omaha.
The investigators discovered that some regenerated liver cells
found in the female rats did contain the Y chromosome, meaning they had to have originated in the marrow.