Treatment consists of an acute phase (during which remission of all symptoms is induced); a continuation phase, during which remission is preserved; and a maintenance phase during which susceptible patients are protected against the recurrence of subsequent major depressive episodes
Still, our findings indicate that, in most individuals presenting with a major depressive episode
without a prior manic or hypomanic episode, unrecognized bipolarity does not appear to be a major determinant of treatment resistance.
If these factors were wholly to blame for depression -- as dictated by the shared vulnerability hypothesis -- then we would expect former heavy smokers and current smokers would have an equal likelihood of experiencing a major depressive episode
Of the 221 women, 129 (58%) transitioned to post menopause over the 9 years and 69 (31%) experienced at least one major depressive episode
For the first time, their physicians will have the option to prescribe an agent specifically indicated to prevent their seasonal major depressive episodes
However, the work group added a footnote to clarifying that normal bereavement might resemble a depressive episode but that a major depressive episode
would be characterized by feelings of worthlessness, suicidal ideas, psychomotor retardation, and severe impairment of overall function.
1 List of Tables Table 1: Classification and Criteria of Major Depressive Disorder (DSM-IV) and Major Depressive Episode
(ICD-10) 14 Table 2: Subtypes of Major Depressive Disorder 15 Table 3: Severity of Depressive Episodes according to ICD-10 and DSM-IV Diagnostic Criteria 17 Table 4: Treatment Guidelines for Major Depressive Disorder 19 Table 5: Most Prescribed Drugs for MDD by Class in the 7MM and Australia, 2013 21 Table 6: Leading Treatments for MDD, 2013 27 Table 7: Product Profile - Abilify 29 Table 8: Safety of Abilify - Five Most Frequently Reported Adverse Events 31 Table 9: Abilify SWOT Analysis, 2014 31 Table 10: Global MDD Sales Forecasts ($m) for Abilify, 2013-2023 32 Table 11: High-Prescribing Physicians (Non-KOLs) Surveyed, by Country 41 1.
The 139 patients with high medical comorbidity were significantly more likely than were those with low medical comorbidity to present in a current major depressive episode
WASHINGTON -- Current major depressive episode
and drug abuse appear to be significant predictors of suicidal ideation in postpartum women, according to a study of 400 women with a history of neuropsychiatric illness who were followed before and after delivery.
In the United States alone, more than 15 million people experience a major depressive episode
each year, and nearly 17 percent of adults will experience major depression in their lifetime.
All had a current major depressive episode
of at least 8 weeks' duration at study entry, as well as a score of 30 or more (mean of 36) on MADRS-CR.
For example, a major depressive episode
is reported by 14% of adolescents with substance use disorders, especially in the older age range.