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Digitized assessment of mammographic breast density in patients who received low-dose intrauterine levonorgestrel in continuous combination with oral estradiol valerate: a pilot study.
In a retrospective analysis of data from another phase 3 study, treatment with Wyeth's investigational compound bazedoxifene (BZA) alone did not appear to increase mammographic breast density in postmenopausal women with osteoporosis compared to raloxifene (the active comparator) or placebo over two years.
SAN ANTONIO -- Topical afinoxifene proved effective for the treatment of cyclic mastalgia and also showed potential for reduction of mammographic breast density in separate phase II clinical trials presented at a breast cancer symposium sponsored by the Cancer Therapy and Research Center.
Results of the trial were mixed: Five of 32 afinoxifene-treated patients and 0 of 29 placebo-treated patients with 50%-80% baseline mammographic breast density showed at least a 10% reduction in density after 4 months, but there was no significant difference between the two study arms at 6 months.